Life at various scales, from molecules, cells, to organisms, can be viewed as a dynamic self-assembling system. To engineer nature-inspired self-assembled molecular systems, which have can communicate with cells and regulate biological events, is one of the grand goals that is highly relevant to scientific areas ranging from synthetic biology, nanotechnology, to regenerative medicine.

 

The research in our group is addressing this challenge by pursuing structural DNA and RNA nanotechnology to gain structural, mechanical, and biological insights into manipulation of matter at the nanoscale, and to exploit DNA/RNA/protein self-assembled nanodevices to program cellular behaviors and pathways.

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